RecruitingEarly Phase 1Drug trialAcute and Chronic Effects of Oral Ketones in Subjects With HFrEF and DiabetesThis study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not dependent upon insulin or influenced by insulin resistance.