RecruitingPhase 3Clinical trialMotivational Interviewing and Mindfulness-Oriented Recovery EnhancementThe purpose of this study is to 1) examine barriers and facilitators to implementation of MI and MORE for polysubstance use and evaluate strategies for optimizing training, fidelity, and clinic uptake, and 2) evaluate patient outcomes related to the effectiveness of MORE decreasing opioid, tobacco, and other drug use.