RecruitingClinical trialMicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRialThis study is a dynamically adjustable prospective longitudinal study designed to capture biospecimen (biopsy, blood, surgical) and multimodal treatment-related data (imaging, dosimetry, clinical) before, during, and after treatment with definitive-intent chemoradiotherapy for patients with locally advanced cervical and pancreatic cancer.