RecruitingClinical trialUse Muscadine Wine Nutraceuticals to Improve Brain Health, Cognition, and Mental HealthPrevious studies have shown that polyphenol-rich foods can positively affect cognitive functions, memory, and mood in humans. We hypothesize that both acute and chronic intake of muscadine wine polyphenols will improve cognitive performance and mood through regulating the HPA axis, alleviating inflammation and oxidative stress, and/or inhibiting monoamine oxidase activities