RecruitingPhase 2Diagnostic testImproving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)This study is a randomized Phase 2 trial to determine the feasibility of real-time electrocorticographic monitoring of spreading depolarizations (SD) to guide implementation of a tier-based protocol of intensive care therapies, aimed at SD suppression, for the management of patients who have undergone acute operative treatment of severe traumatic brain injury.