RecruitingPhase 1Biological interventionAutologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IATThis is a clinical trial for chronic pancreatitis (CP) patients undergoing total pancreatectomy with islet autotransplantation (TP-IAT). Participants will be randomized to either bone marrow-derived mesenchymal stem cells (MSCs) or control with the standard of care. Participants will be followed for one-year post-transplant.