RecruitingEarly Phase 1Drug trialSGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research PlanThe study team will examine the effects of SGLT2i (and SGLT2i-induced increases in plasma ketone concentrations) on skeletal muscle and cardiac ketone uptake, skeletal muscle bioenergetics, cardiopulmonary exercise capacity, and patient-reported functional outcomes.