RecruitingPhase 2Drug trialMinimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE)This is a phase II interventional study evaluating the use of minimal residual disease by next generation sequencing to defer autologous hematopoietic stem cell transplantation (AHCT) in patients with newly diagnosed multiple myeloma (cohort A) and amyloidosis (cohort B).