RecruitingPhase 1Drug trialStudy of ctDNA Guided Change in Tx for Refractory Minimal Residual Disease in Colon AdenocarcinomasThis is a phase 1b, prospective, single arm, non-randomized, open-label clinical trial determining the efficacy of adjuvant trifluridine and tipiracil (TAS-102) in combination with irinotecan in patients with ctDNA positive colon adenocarcinoma.