RecruitingDrug trialRisk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced ConstipationThe research objective is to characterize the risk of a major adverse cardiovascular event (MACE) among new users of naldemedine versus new users of lubiprostone and new users of naloxegol as comparator opioid induced constipation (OIC) medications.