RecruitingPhase 1Biological interventionAdjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar DepressionThe overall objective of the investigators is to assess the therapeutic efficacy and tolerability of Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs) isolated from hematogenous bone marrow for treatment of treatment-resistant bipolar depression patient (TRBD).